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Poor blood and stem/progenitor cell supplies underlie wound healing impairment in diabetic patients.Induced pluripotent stem cells (iPSs) have great therapeutic potential;however,it is not clear whether iPSs can promote wound healing are unknown.Directly application of iPSs on a body or wound surface has not yet been reported.This study aimed to demonstrate the effect and associated mechanisms of topically applied iPSs on wound healing in diabetic mice.In streptozocin-induced type 1 diabetic mice,we found that iPSs accelerated skin wound healing,and promoted re-epithelialization and angiogenesis,while increasing expression of proangiogenic factors and receptors in the diabetic wound.