【摘 要】
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We found a group of non-platelet RNA-containing particles (NPRCPs) in human blood that can aggregate, fuse into non-nucleated cells and further differentiate into Oct4-expressing nucleated cells.In th
【机 构】
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Beijing Khasar Medical Technology Co.China
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We found a group of non-platelet RNA-containing particles (NPRCPs) in human blood that can aggregate, fuse into non-nucleated cells and further differentiate into Oct4-expressing nucleated cells.In this study, we purified NPRCPs in GFP-transgenic mouse blood.NPRCPs are about 1 to 5 m, have a thin bi-layer membrane, contain short RNAs and microRNAs, and express Oct4, sox2,and DDX4.To confirm the function of NPRCPs in vivo, we transplanted GFP-transgenic-micederived NPRCPs into acute kidney ischemia-damaged Balb/C wild-type mice via tail-vein.
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