【摘 要】
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The regulation of cardiac differentiation is critical for maintaining normal cardiac development and function.The precise mechanisms whereby cardiac differentiation are regulated remain tmcertain.Here
【机 构】
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Zhengzhou University China
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The regulation of cardiac differentiation is critical for maintaining normal cardiac development and function.The precise mechanisms whereby cardiac differentiation are regulated remain tmcertain.Here, we determined that EGF is essential for cardiogenesis and is functionally linked to GATA-4 in inducing the cardiac differentiation of P19CL6 cells.Moreover, EGF, a novel target of GATA-4, also regulates cell proliferation by modulating the cell cycle regulatory protein cyclin D1.
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