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  5. Mechanism of SNP in intron affecting the expression of distal gene by spatial interaction

Mechanism of SNP in intron affecting the expression of distal gene by spatial interaction

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：qq1094795388
【摘 要】
：
Background: Trans-eQTL can affect the expression of distal gene by inter or intra-chromosomal interaction, which may give rise to disease and cancer.But the mechanism remained unknown, we supposed tha
【作 者】
：
谢小韦 熊远妍 戴志明 黄俊峰 罗镇华 
【机 构】
：
干细胞与功能基因组实验室,中山大学,510006
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
SNP Hi-C TERT cancer 
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　　Background: Trans-eQTL can affect the expression of distal gene by inter or intra-chromosomal interaction, which may give rise to disease and cancer.But the mechanism remained unknown, we supposed that SNP firstly changes the histone modification level of where it locates by affecting the binding of histone methylase, then this effect is transferred to distal target gene by inter or intra-chromosomal interaction.TERT (telomerase reverse transcriptase) is the protein component of telomerase whose expression plays a role in senescence and oncogenesis.
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