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  5. Study on the Relationships between Histone Modifications and Gene Expression Levels in the Human H1

Study on the Relationships between Histone Modifications and Gene Expression Levels in the Human H1

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：reinhardwu
【摘 要】
：
Background: It is well known that histone modifications can control gene expression, and the data of histone modifications have grown exponentially by the next-generation sequencing techniques.Based o
【作 者】
：
苏文霞 李前忠 左永春 
【机 构】
：
理论生物物理实验室,物理科学与技术学院,内蒙古大学,呼和浩特,010021 理论生物物理实验室,物
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
histone modification gene expression regional distribution embryonic stem cells 
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　　Background: It is well known that histone modifications can control gene expression, and the data of histone modifications have grown exponentially by the next-generation sequencing techniques.Based on these data, many theoretical works for epigenetics researches could be proceed.But dealing with such big data is quite difficult and time-consuming, which really is a challenge for computational biology.The epigenetic modification is cell-type specific, so we chose one important cell type, the human embryonic stem (ES) cell, to study the relationship between histone modifications and gene expression levels.
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