【摘 要】
：
A series of some new 4-piperazinquinazoline derivatives 3a~3i have been synthesized by reaction of substituted 4-piperazinyl quinazoline and methyl hydrazinecarbodithioate Schiff base and in vitro ant
【机 构】
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School of Biomedical & Chemical Engineering,Liaoning Institute of Science and Technology,Liaoning Be
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
A series of some new 4-piperazinquinazoline derivatives 3a~3i have been synthesized by reaction of substituted 4-piperazinyl quinazoline and methyl hydrazinecarbodithioate Schiff base and in vitro anticancer activity of these novel compounds against MCF-7(human breast cancer),A549(human lung cancer) and PC-3(human prostatic cancer) cell lines was evaluated using colorimetric MTT assay.Compared with the standard drug Lapatinib,five compounds(3a,3f,3g,3h and 3i)exhibited more greatly increased cytotoxicityagainst the three cancer cell lines.
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