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A 59-year-old man was admitted to the emergency department with an acute myocardial infarctio n (AMI) due to left main coronary artery (LMCA) occlusion.An emergent percutaneous coronary angiogram was performed and showed total occlusion of the mid-shaft of the LMCA, which resulted in insufficient perfusion and the patients condition worsened.Because an intra-aortic balloon pump (IABP) could not provide adequate organ perfusion pressure, veno-arterial extracorporeal membrane oxygenation (ECMO) and percutaneous transluminal coronary angioplasty (PTCA) were performed.The patient was transferred to the Cardiac Surgical Department for surgical revascularization and coronary artery flow was re-established, successfully weaned from ECMO after 86 hours of support, and discharged to home with recovered left ventricular function 12 days later.