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The generation of neocortex interneurons approximately starts from E9.5 and ends at E18.5.Previous studies have revealed that a portion of early generated interneurons(EGIns)in the hippocampus developed into a subclass of interneurons with widespread axonal arbors and can act as hub neurons which may modulate the synchronized activity of the hippocampus network.However,the subtypes and characteristics of EGIns in neocortex are not well understood.In this study,combining immunohistochemistry with retrograde labelling and whole-brain reconstruction technologies,we studied the subtypes and characteristics of EGIns.On the basis of immunohistochemical data,we found that the EGIns are distributed in the Layer2-6 of the neocortex,and most majority of them were immunopositive for somatostatin(SOM).Using a retrograde labelling strategy,we showed that a portion of EGIns were nNos-positive long-projection interneurons.