论文部分内容阅读
Bisphenol A(BPA),a kind of representative of the environmental endocrine disruptor,is widely used for plastic products,such as food and beverage packaging materials carbonate polyesters,epoxy resins,dental fillers and other related products manufacturing.Alzheimers disease(AD),is the most common form of dementia and is characterized chronic and progressive neurodegeneration leading to increase cognitive and memory dysfunction.The progressive accumulation of hyperphosphorylated tau is a major hallmark of AD pathology.Tau hyperphosphorylation is caused by an imbalance between the activity of protein kinases and phosphatases.The protein kinases and phosphatases that are most implicated are glycogen synthase kinase-3 β(GSK-3β),cyclin dependent kinase 5(CDK5)and protein phosphatase-2A(PP2A).Our previous experiment have shown that exposure to BPA contributes to the adult and offspring mice tau hyperphosphorylation,but the mechanism remains unknown..So we give the perinatal(P7-PND21)mice different doses(Control/2/10/100 μg/kg/day)of BPA,then observe the changes of phosphorated tau protein in offspring male mice and which mechanism involved in this change.