【摘 要】
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The catalytic asymmetric Michael reaction is one of the most important carbon-carbon bond formation reactions.However, β, γ-unsaturated α-ketoamides as a new class of Michael acceptors were less studi
【机 构】
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College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450052,China
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The catalytic asymmetric Michael reaction is one of the most important carbon-carbon bond formation reactions.However, β, γ-unsaturated α-ketoamides as a new class of Michael acceptors were less studied than the corresponding ester and phosphonate.[1] And the direct catalytic asymmetric Michael reaction of α-hydroxyacetophenone as donors to β, y-unsaturated α-ketoamides has not been reported.To this end, we report our dinuclear Zinc Catalyst 1 prepared in situ, which controls the addition of α-hydroxyacetophenone to β, γ-unsaturated α-ketoarnides with excellent enantioselectivities.
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