【摘 要】
：
Amphidinolactone B (1),1 isolated from dinoflagellate Amphidinium sp.is a novel 26-membered macrolide with potent cytotoxicity against L1210 murine leukemia and human epidermoid carcinoma KB cell line
【机 构】
：
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay,Kowloon
论文部分内容阅读
Amphidinolactone B (1),1 isolated from dinoflagellate Amphidinium sp.is a novel 26-membered macrolide with potent cytotoxicity against L1210 murine leukemia and human epidermoid carcinoma KB cell lines.The characteristic structural feature of 1 is the 2,2,3,5-tetrasubstituted tetrahydrofuran subunit 2which distinguishes 1 from the related 26-membered macrolides, amphidinolide B, D, G, and H congeners.
其他文献
阿魏酰基甘油脂是由单阿魏酰基甘油和二阿魏酰基甘油组成的一类水溶性的阿魏酸的甘油脂类物质,这类物质可用作化学、食品和医药工业的紫外吸收剂和抗氧化剂.为进一步提高生物合成FGs的效率,本研究开发了一个离子液体体系酶催化阿魏酸乙酯和甘油酯交换反应的方法,该方法可得到MFG的最大产率为63.72±1.26％和DFG的最大产率为78.80±2.09％.由于Novozym 435的1,3位选择性作用和离子液体
Evaluation of the chemical constituents is vital for establishing the quality control profile and standardization of herbal extracts [1-4].This vitalizes the investigation of metabolites having variou
结构脂质(Structured lipids,SLs)是指所有经化学或者酶法进行脂肪酸重组的天然脂质,包括脂肪酸在甘油三酯中位置的改变和(或)脂质脂肪酸组成的变化,而低热量SLs一般是指将短碳链脂肪酸(C2～C4)与长碳链脂肪酸(C16～C22)一起与甘油结合形成的新型脂质.由Nabisco食品公司生产的Salatrim就是在美国市场上深受广大消费者青睐的低热量SLs.低热量SLs有两种结构类型,
在"全域城市化、新型工业化、农业现代化、城市智慧化"的"四化统筹"城市发展战略指引下，大连市的城市智慧化建设工作得以快速推进、在城市管理创新和政府服务实践中取得了明显成效。目前已形成《市委市政府关于推进城市智慧化建设的意见》和《大连市城市智慧化总体发展规划(2014-2020)》等指导性文件构成的城市智慧化顶层设计总体框架，构建了以城市基础设施和智慧产业发展为支撑，公共管理和民生服务专项工程协力发
Natural products represent a source of remarkable chemical diversity for drug discovery.Most of the bioactive natural products are chiral organic compounds with complex structures such as chiral quate
不对称催化是有机化学发展最为活跃的研究领域之一.手性有机小分子催化因其催化剂不含金属、绿色低毒、价廉易得而成为不对称催化领域中的研究热点.为解决"催化剂用量较大、与产物难于分离"这些瓶颈问题,多相不对称催化(heterogeneous asymmetric catalysis)近年来受到人们的关注.我们采用"自下而上"(bottom-up)[1]的策略,将手性功能化有机小分子砌块通过共价键联作用,
Nucleoside analogues have displayed significant antivirus and anticancer activities.The synthesis of nucleoside analogues was focused on the modification of the heterocyclic base or sugar or both moie
Enantioselective desymmetrization of meso or prochiral compounds is one of the most important strategies in asymmetric catalysis.In particular, the desymmetrization of diols has captured much attentio
Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides to electron-deficient alkenes has arguably been one of the most ideal synthetic strategies for the stereoselective construction of h
在手性合成化学中,相关有机合成反应的催化效率及立体选择性的控制与手性配体的结构密切相关,手性配体及其金属配合物是其成败的关键因素.多年来,在不对称催化研究中,发展新颖、高效的手性配体一直以来受到化学家的极大关注,大量新型配体被合成出来,但是手性骨架仍然有限,主要来源于氨基酸、糖类、平面手性的二茂铁衍生物及C2轴手性化合物[1].近年来,我们课题组基于多类手性骨架为解决部分手性合成反应开展了新型配体