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  5. Activated microglia promote oxygen-glucose deprivation/reperfusion induced retinal ganglion cells ap

Activated microglia promote oxygen-glucose deprivation/reperfusion induced retinal ganglion cells ap

来源 :第八届中国眼科学和视觉科学研究大会 | 被引量 : 0次 | 上传用户：ulysseschen
【摘 要】
：
Purpose Retinal ischemia/reperfusion(I/R)injury causes the death of retinal ganglion cells(RGCs),however the underlying mechanisms by which IR injury induces RGCs death are not clarified.Increasing ev
【作 者】
：
Li Fei Su Wenru Wan Peixing Zhuo Yehong 
【机 构】
：
State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University 430030
【出 处】
：
第八届中国眼科学和视觉科学研究大会
【发表日期】
：
2016年5期
【关键词】
：
OGD/R injury retinal ganglion cells caspase-8 TLR4 NLRP3 inflammasome IL-1β 
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　　Purpose Retinal ischemia/reperfusion(I/R)injury causes the death of retinal ganglion cells(RGCs),however the underlying mechanisms by which IR injury induces RGCs death are not clarified.Increasing evidence suggests that microglia are activated during IR injury and TLR4 signaling is triggered by CNS IR injury and plays an important part in the death of neurons.
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