A single-amino acid substitution in nsp14 of the coronavirus mouse hepatitis virus abolished guanine

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：chenmojay

【摘要】

：

【作者】

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Ruangang Pan Yu Chen Deyin Guo

【机构】

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State Key Laboratory of Virology and Modern Virology Research Centre,College of Life Science,Wuhan U

【出处】

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第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会

【发表日期】

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2015年6期

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Coronaviruses possess a cap structure at the 5ends of viral genomic RNA and subgenomic RNAs,which is generated through consecutive methylations by virally encoded guanine-N7-methyltransferase(N7-MTase) and 2-O-methyltransferase (2-O-MTase).The coronaviral N7-MTase is unique for its physical linkage with an exoribonuclease (ExoN) harbored in nonstructural protein 14 (nsp 14) of coronaviruses.

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A single-amino acid substitution in nsp14 of the coronavirus mouse hepatitis virus abolished guanine

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