High-throughput screening anti-Ebola virus compounds that block Ebola virus-like particle entry from

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户：fjfhmtv

【摘要】

：

As Ebola virus outbreak in West Africa continues,the spread of the virus to other regions in the world is a serious concern.Although antibody-based therapy has been shown to be effective in a macaque

【作者】

：

Rong Ma Yan Li Qinqin Wang Junfu Li Jinghua Yan Huanqin Dai Fuhang Song George Fu Gao Lixin Zhang

【机构】

：

Key Laboratory of Pathogenic Microbiology & Immunology Institute of Microbiology,Chinese Academy of

【出处】

：

第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会

【发表日期】

：

2015年6期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

As Ebola virus outbreak in West Africa continues,the spread of the virus to other regions in the world is a serious concern.Although antibody-based therapy has been shown to be effective in a macaque model and has been used for the treatment of a few patients,the current supply of such drugs is very limited.Small molecule drug screening might be a good approach to discover and develop anti-Ebola virus drugs.

其他文献

Marine virus mediated sphingolipid metabolic-regulation and the apoptosis-inducing in marine Emilian

Marine viruses that infect phytoplankton are recognized as a major ecological and evolutionary driving force,shaping community structure and nutrient cycling in the marine environment.Coccolithophores

会议

慢性乙型肝炎患者外周血中双阴性T细胞表面PD-1表达特征

目的：分析慢性乙型肝炎(CHB)患者外周血中T细胞亚群表面程序性死亡受体1(PD-1)表达的变化特点.方法：采用流式细胞仪回顾性分析10例慢性乙型肝炎患者及10例健康对照者外周血中T细胞及其亚群CD4-CD8-T细胞、CD4+CD8-T细胞、CD4-CD8+T细胞、CD4+CD8+T、CD4+CD8+细胞表面PD-1的表达水平.结果：与健康对照组相比,CHB患者组T细胞及其主要亚群CD4-CD8-

会议

慢性乙型肝炎CD4-CD8-T细胞PD-1病毒载量

Efficient labeling of Pseudorabies Viruses with Quantum Dots for Single-particle tracking virus endo

Virus labeling is essential for getting knowledge of virus-cell interactions.Quantum dots (QDs),as a photochemical stable nanomaterial,make long-time tracking possible.According to the fact that virus

会议

家蚕核型多角体病毒泛素修饰靶标的鉴定

家蚕核型多角体病毒(Bombyx mori nucleopolyhedrovirus,BmNPV)是能够自身编码泛素基因的杆状病毒属病毒成员,而泛素-蛋白酶体系统在BmNPV的早期复制过程中扮演了重要角色,所以在BmNPV侵染过程中,病毒及宿主泛素化蛋白的鉴定对于研究泛素-蛋白酶体系统在病毒复制中所起得作用显得尤为重要。本研究借助Red重组和杆状病毒表达系统构建出只融合表达泛素-myc-his蛋白

会议

泛素家蚕核型多角体病毒泛素化蛋白LC-MS/MS

Dual-gRNAsand gRNA-miRNA-gRNA ternary cassette combined CRISPR/Cas9 system and RNAi approach promote

Purpose:To investigate the potential use of CRISPR/Cas9 approach for eradicatinghepatitis B virus(HBV)infection,we designed and screened for the most effective gRNAs against HBV of genotypes A-D,and d

会议

HBVcccDNACRISPR/Cas9RNAi

Failure recovery of circulating NKG2D+CD56dim NK Cells in HBV-associated hepatocellular carcinoma af

Purpose:To investigate the changes of NK profile in peripheral blood after surgery and tumor tissues of hepatocellular carcinoma(HCC)patients,as well as the underlying reason.Experimental Design: Peri

会议

NK cellsNKG2DHCCsMICATGF-β

Dysfunctional Characteristics of antibody-dependent cellular cytotoxicity mediated by CD56+Natural K

Objective:As an important cooperated immune response of innate and adaptive immunity,CD56+ NK cell-mediated antibody-dependent cellular cytotoxicity(NK-ADCC)is of considerable interest in viral infect

会议

NK cellsADCCHCVepitopeneutralizing antibodies

Dissecting the Temporal Precision of Influenza Virus Entry via Endocytosis by Quantum Dots based Sin

Influenza A virus (IAV) causes periodical epidemics and pandemics responsible for considerable severe disease cases and casualties,and becomes one of the most hazardous worldwide public health threats

会议

Identification of Type Ⅰ IFN in Chinese giant salamander (Andrias davidianus) and the response to an

The type Ⅰ IFNs play a major role in the first line of defense against virus infections.In this study,the type Ⅰ IFN gene designated gsIFN was identified and characterized in the Chinese giant salaman

会议

Chinese giant salamanderAndrias davidianusType Ⅰ IFNantiviral activityinnate

Establishment of a novel and highly permissive cell line for the efficient replication of cyprinid h

Haematopoietic necrosis of gibel carp(Carassius auratus gibelio)is caused by cyprinid herpesvirus 2(CyHV-2)and has caused huge economic losses in aquaculture worldwide.Currently the isolation and prop

会议

Gibel carp (Carassius auratus gibelio)BrainCell lineCyprinid herpesvirus 2 (C

High-throughput screening anti-Ebola virus compounds that block Ebola virus-like particle entry from

其他学术论文