【摘 要】
：
Aptamers are single-stranded oligonucleotides binding to target molecule with high specificity and affinity.Compared with antibody,aptamers have lots of advantages,such as wide range of targets,easy t
【机 构】
：
Engineering Research Center of Molecular Medicine,Ministry of Education and Institutes of Molecular
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Aptamers are single-stranded oligonucleotides binding to target molecule with high specificity and affinity.Compared with antibody,aptamers have lots of advantages,such as wide range of targets,easy to synthesis,easy to transport,no immunogenicity.However,studies shown that rapid degradation by ubiquitous nucleases limited the aptamer efficacy and the half-life of the aptamer is short,which is limit the application as aptamer drugs.Tumor angiogenesis plays an important role in tumor development,which has an important sector considered in the treatment of tumors.
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