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Objective: To evaluate the safety and short-to mid-term efficacy of CT-guided 125I brachytherapy on intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for hepatocellular carcinoma (HCC).Methods: From November 2004 to May 2008, ten patients with intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for HCC underwent 125I brachytherapy under the guidance of computed tomography.They were followed up for 4-44 months after brachytherapy and the treatments efficacy was evaluated.