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Objective: To investigate the application of free anterolateral perforator flap or medial sural artery perforator flap in the reconstruction of soft tissue defects following oral and maxillofacial tumor resection.Methods: Soft tissue defects after oral and maxillofacial tumor resection were reconstructed in 35 patients through the attachment of a free anterolateral thigh perforator flap or a free medial sural artery perforator flap by vascular anastomosis.The flap area used ranged from 5 cm x 8 cm to 10 cm x 15 cm.