Atp6v1c1 Facilitates Breast Cancer Growth and Metastasis through Mtorc1 Pathway

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户：helpothers

【摘要】

：

【作者】

：

Yi-Ping Li Shengmei Feng Guochun Zhu Lianfu Deng Wei Chen

【机构】

：

Department of Pathology University of Alabama at Birmingham USA

【出处】

：

2014第七届世界癌症大会

【发表日期】

：

2014年12期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in cancers, including breast cancer.Recent studies have shown that mTORC 1 senses lysosomal amino acids through an inside-out mechanism that requires vacuolar H+-ATPase activity.

其他文献

The Mechanism of Demethylase FBXL10 in Gastric Cancer Cell Proliferation and Autophagy

The F-box and leucine-rich repeat protein 10 (Fbx110, also known as Jhdm1b or Kdm2b) has many roles concerned with the regulation of proliferation, growth, differentiation, senescence and apoptosis in

会议

Ribosomal S6 Kinase 2(RSK2) is a Critical Molecule in Cell Transformation, Apoptosis and Colitis Ass

RSK2 is a member of Ribosomal S6 kinases family, which is downstream of the mitogen-regulated Ras/ERK-MAP kinase signaling pathway.We found that RSK2 phosphorylates caspase-8 and Thr263 was identified

会议

Induction of the Liver Cancer-down-regulated Long Noncoding RNA uc002mbe.2 Dictates Trichostatin-ind

Recent publications showed that aberrant tncRNA expression plays an important role in hepatocarcinogenesis.Potentially, lncRNAs can become diagnostic and prognostic markers as well as the therapy targ

会议

Adrenomedullin and Tumor Angiogenesis: From Discovery towards Translational Research

Adrenomedullin (AM) is a multifunctional peptide hormone involved in cellular proliferation, survival and angiogenesis.AM expression isup-regulated by hypoxia (a typical feature of solid tumours) and

会议

Effects of HPV-16 Oncoproteins on Angiogenesis in Lung Cancer Cells

Lung cancer is the leading cause of cancer-related mortality worldwide.Cigarette smoking is the most important risk factor of lung cancer, but infection with high-risk human papillomavirus (HPV) may p

会议

Tempo Combine Treatment with Hyperthermia Switch the Cell Death from Apoptosis to Autophagy

Heat stress or a superoxide disrnutase mimic nitroxide, Tempo, induces apoptosis, while their combination causes non-apoptotic cell death.However, the mechanism for this switch remains unclear.In this

会议

Anti-tumor Effect of a Novel Soluble Recombinant Human Endostatin: Administered as a Single Agent or

Angiogenesis has become an attractive target in cancer treatment.Endostatin is one of the potent anti-angiogenesis agents.Its recombinant form expressed in the yeast system is currently under clinical

会议

Ribonucleases in Tumor Angiogenesis and Cancer Progression

Secreted ribonucleases (RNASEs) are the only enzyme family that is vertebrate-specific.In addition to the universal ribonucleolytic activity, many members of this family have unique biologic activitie

会议

Prognostic Significance of the Aggregative Perivascular Growth Pattern of Tumor Ceils in PCNS-DLBCL

Primary central nervous system tymphomas, predominantly diffuse large B-cell lymphomas (PCNSDLBCL) are aggressive form of non-Hodgkin lymphoma whose growth are restricted to the central nervous system

会议

Genomic and Epigenomic Investigation of Oncogenic Pathways for Therapeutic Targets in Malignant Aggr

Diffuse large B-cell lymphoma (DLBCL) is the most common and devastating form of lymphoma in the world.The incidence of DLBCL, ranked fifth of all cancer types in the United States, has increased by a

会议

Atp6v1c1 Facilitates Breast Cancer Growth and Metastasis through Mtorc1 Pathway

其他学术论文