Ribosomal S6 Kinase 2(RSK2) is a Critical Molecule in Cell Transformation, Apoptosis and Colitis Ass

来源 :2014第七届世界癌症大会 | 被引量 : 0次 | 上传用户：skybey

【摘要】

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【作者】

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Cong Peng Xu Zhang Xiang Chen

【机构】

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Department of Dermatology XiangYa Hospital, Central South University China

【出处】

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2014第七届世界癌症大会

【发表日期】

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2014年12期

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　　RSK2 is a member of Ribosomal S6 kinases family, which is downstream of the mitogen-regulated Ras/ERK-MAP kinase signaling pathway.We found that RSK2 phosphorylates caspase-8 and Thr263 was identified as a novel caspase-8 phosphorylation site.Phosphorylation of Thr263 is associated with the ubiquitination and degradation ofcaspase through the proteasome pathway.Results suggested that RSK2 regulates caspase-8 stability through its phosphorylation of this caspase.

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Ribosomal S6 Kinase 2(RSK2) is a Critical Molecule in Cell Transformation, Apoptosis and Colitis Ass

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