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Cell-penetrating peptides provide a unique platform to create a new generation of cancer therapeutics with enhanced efficacy and diminished toxicity.In our previous study, enhanced expression of tolllike receptor 2 (TLR2) was observed in acute myeloid leukemia (AML) cells.Screening of a phage display peptide library using Biopanning and Rapid Analysis of Selective Interactive Ligands (BRASIL) identified a TLR2-binding peptide motif, Pep2.