Evaluation of the biocompatibility of packing materials for a catheter

• 作 者: WoongJinBae;JinBongChoi;KangSupKim;SuJinKim;HyukJinCho;USynHa;SungHooHong;JiYoulLee;SaeWoongKim;
• 机 构: Seoul St.Mary's Hospital,College of Medicine,The Catholic University of Korea,Seoul,Korea
• 出 处: 华夏医学论坛·泌尿生殖2015暨亚太性医学年会2015
• 发表日期: 2015年期

　　Objective: The necessity for biocompatible packing materials has become important as the increasing of using implantable medical devices.In this study,we investigated the biocompatibility of platinum-catalyzed silicone(Ecoflex(@))as a packing material in the rats.Methods: Twenty 12-week white male Sprague-Dawley rats were used in this study.The rats were assigned to four experimental groups: control,non-coating metal,polydimethylsiloxane(PDMS),and Ecoflex(@).After a ball-shaped materials coated with PDMS and Ecoflex(@)were implanted into the bladder of rats,we compared the biocompatibility of non-coating metal,PDMS,and Ecoflex(@)by analyzing changes in the levels of macrophages and inflammatory cytokines in the bladder.Results: Increased macrophage activity in the urothelium of the bladder was observed in PDMS and Ecoflex(@).However,the increasing macrophage activity in PDMS and Ecoflex was not higher than non-coating metal(P<0.05).Increased inflammatory cytokine such as IL-1β,IL-6,and TNF-α in PDMS and Ecoflex(@)were showed significantly difference compared with those of non-coating metal(P<0.05).Conclusions: In our study,we suggested that PDMS and Ecoflex(@)might be used as safe packing materials for a catheter-intergrated bladder pressure sensor.