【摘 要】
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Methods:The records cervical cancer patients with squamous cell carcinoma(stage IB to IVA)underwent definitive radiotherapy in year 2009-2013 were retrospec
【机 构】
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Medical Physics Master Degree Program,Department of Radiology,Chiang Mai University,Chiang Mai,Thail
【出 处】
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The 15th Asia-Oceania Congress of Medical Physics (AOCMP2015
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Methods:The records cervical cancer patients with squamous cell carcinoma(stage IB to IVA)underwent definitive radiotherapy in year 2009-2013 were retrospective studied.The patients received the totally cumulative dose in EQD2 at point A ranged from 83.6 to 86.1 Gy.The total 130 patients were separated into 2 groups based on OTT recommended by ABS,OTT≤56 day(group1)and >56 day(group 2)and the relationship between the treatment outcomes was analyzed using Kaplan-meier,log-rank test,Cox regression,univariate and multivariate analysis(MVA)and Chi-square test.Results:OTT ranged 44-88 day.EQD2 ranged 83.6-86.1 Gy.The local control rate(p=0.681),disease metastasis free rate(p=0.867),Disease Free Survival(DFS)(p=0.769),cause specific survival(p=0.605)and Overall Survival(OS)(p=0.779)were not significantly different between 2 group.MVA identified tumor size(p=0.016 and p=0.014)as the prognostic factor of DFS and OS.There was no statistical significance in both acute and late complication [skin(p=0.922,N/A),subcutaneous tissue(p=0.558,p=1.000),Gastrointestinal(GI)(p=0.682,p=0.474)and Genitourinary(GU)(p=1.000,p=1.000),respectively].The cumulatively rectal dose(in EQD2)was further analyzed,<70 Gy3(group1)and ≥70 Gy3(group2),there were not significance different in acute GI and late GI complication(p=0.422 and p=0.459).Conclusion:The treatment outcome; local control,survival and complications,were not influence by OTT.Tumor size greater than 4 cm was the prognostic factor of DFS and OS.
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