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Objective Efficiency as a network measure was introduced firstly to express the capacity of networks to facilitate information exchange and was the global measures of network integration.The efficiency with which two nodes communicate was defined to be inversely proportional to the shortest distance between these nodes.The global efficiency of the network is the average of the efficiency over all pairs.Local efficiency is a nodal measure of the average efficiency within a local subgraph or neighborhood.While global efficiency is related to the path length,local efficiency is related to the clustering coefficient.Here,DTI tractography and graph theoretical approaches were used to compare the differences of the local and global efficiency in the brain structural networks of the depression and the healthy.