Analysis of Lung Tumor Initiation and Progression in Transgenic Mice for Cre-Inducible over-Expressi

• 作 者: YangWang[1]ZhidongXu[2]Jian-HuaMao[3]Ming-SzuHung[4]David.Hsieh[2]AlfredAu[5]DavidM.Jablons[2]LiangYou[2]
• 机 构: Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Capital Medical University,Beijing, Chin
• 出 处: 中国医师协会胸外科医师分会2015年会、第六届全国胸外科学术大会暨第八届浙江省胸部肿瘤论坛
• 发表日期: 2015年期

　　Background:Lung cancer is the leading cause of morbidity and death worldwide.Although the available lung cancer animal models have been informative and further propel our understanding of human lung cancer,they still do not fully recapitulate the complexities of human lung cancer.The pathogenesis of lung cancer remains highly elusive due to its aggressive biologic nature and considerable heterogeneity, as compared to other cancers.Association of Cul4A amplification with aggressive tumor growth and poor prognosis has been suggested.Our previous study suggested that Cu14A is oncogenic in vitro,but its oncogenic role in vivo has not been studied.