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OBJECTIVE: The aim of this study was to investigate the effect of forest bathing as a natural therapy for elderly patients with stable chronic obstructive pulmonary disease.METHODS: Eighteen elderly patients with stable chronic obstructive pulmonary disease were randomly divided into two groups.One group was sent to a broad-leaved evergreen forest to experience a 4-day trip, and the other group was sent to a city area in Hangzhou as control.Peripheral blood was collected and proportions of natural killer (NK), NKT-like and CD8+ T cells as well as perforin and granzyme-B expression in these cell populations were analyzed by flow cytometry.Pro-inflammatory cytokines and stress hormones were detected as well.Besides, profile of mood states (POMS) evaluation was used to assess the mood state change of subjects.