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Objective:To investigate the association between uric acid (UA) and endothelial function in Chinese hypertensive patients with Metabolic Syndrome (MS).Methods:615 hypertensive patients were enrolled, all hypertensives were divided into two groups: hypertensives with MS (MS group, n=239) and hypertensives without MS (NMS group, n=376).87 age-and sex-matched normotensives served as controls (NC group).Flow-mediated (endothelium-dependent)dilatation (FMD), nitroglycerin-induced (endothelium-independent) dilatation (EID) in the brachial artery were assessed by high-resolution ultrasonography.UA was detected by urease indophenol.