【摘 要】
：
Inflammation plays a pivotal role in the development of abdominal aortic aneurysms (AAAs).The purpose of the study was to elucidate molecular mechanisms that might orchestrate leukocyte recruitment in
【机 构】
：
Department of Cardiology,Shanghai First People's Hospital,School of Medicine,Shanghai Jiao Tong Uni
【出 处】
：
Ready for 2018- the 4th China International Forum on Hyperte
论文部分内容阅读
Inflammation plays a pivotal role in the development of abdominal aortic aneurysms (AAAs).The purpose of the study was to elucidate molecular mechanisms that might orchestrate leukocyte recruitment into the outer wall by determining whether CC chemokines contribute to development of aneurysm degeneration in an nicotine-induced mouse model of AAA and the underlying mechanism.Our results showed that SP600125 (JNK inhibitor) attenuates nicotine-induced aortic aneurysm formation, simultaneously, MCP-1 and RANTES was observed up-regulation significantly in aortic aneurysm lesions compared with normal mouse aorta, and in vitro, nicotine induced the expression of MCP-1and RANTES in both RAW264.7 cells and MOVAS cells in a dose-dependent manner, with an upregulating expression by 0.5ng/ml nicotine but a downregulating expression by 500ng/ml nicotine.Furthermore, the upregulation of expression activation of MCP-1 and RANTES was significantly abrogated by SP600125 or PNU-282987, and transwell migration assay was similar assessed.In conclusion, SP6000125 attenuates nicotine-induced aortic aneurysm formation, nicotine-induced MOVAS cells and RAW264.7 cells express MCP-1 and RANTES in a dose-dependent manner.The expression of chemokines in MOVAS cells induced by nicotine have an effect on RAW264.7 migration, which is likely contribute to the development of aortic aneurysm.
其他文献
Objective:Mitochondrial oxidative stress has been implicated in hypertensive cardiomyopathy.Abnormal Ca2+ handling is thought to be related with triggered activity and mitochondria participate in Ca2+
Objective:To investigate the alteration of renal Nephrin signaling and ultrastructural injury in hypertension state and the effects of recombinant human angiotensin-converting enzyme 2 (ACE2) on these
Introduction:Epidemiological evidence supports an important association between PM2.5 exposure and hypertension.There are reports that PM2.5 induced hypertension with impaired sodium excretion, but th
Oral NaCl produces a greater natriuresis and diuresis than the intravenous infusion of the same amount of NaCl.Gastrin is the major gastrointestinal hormone taken up by renal proximal tubule (RPT) cel
Objective:To explore the contribution of the neddylation in neointima formation after vascular injury and study the mechanisms.Methods:Twelve C57 mice undergoing femoral artery injury, then subcutaneo
Objective:Numerous studies have indicated that long non-coding RNAs (IncRNAs) are involved in the cardiovascular development, as well as pathology, such as heart failure and coronary arterial disease.
Objective:The aim of present study is to construct the profiles of LncRNAs in blood of patients with essential hypertension and healthy controls.Methods:LncRNA microarray was used to screen the LncRNA
Objective:Prognosis of exaggerated morning surge (MS) of blood pressure (BP) remains controversial, possibly due to the ethnic difference in the size of MS.Compared to MS, evidence on morning hyperten
In this study, 23 women with established PE and 32 normal pregnant women were recruited.In human placenta, we detected an elevated C5a deposition in peeclamptic patients, which was colocalized with ma
Objective:Central blood pressure (BP) is suggested to be more closely correlated to target organ damage and cardiovascular events than brachial BP.Outcome-based thresholds for the diagnosis of central