Formal Non-Clinical and Clinical Development Pathway for siRNA Drugs Administered Locally (by Intrav

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户：amwygah021121

【摘要】

：

It is generally accepted that efficient siRNA delivery in vivo is the major hurdle in development of siRNA therapeutics.To overcome this obstacle,we have concen

【作者】

：

Shai Erlich

【机构】

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QuarkPharmceuticals

【出处】

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第五届中国小核酸技术与应用学术会议

【发表日期】

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2015年9期

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It is generally accepted that efficient siRNA delivery in vivo is the major hurdle in development of siRNA therapeutics.To overcome this obstacle,we have concentrated on developing siRNA therapeutics for indications involving cells/tissues to which naked siRNA can be readily delivered.Quark currently has three different synthetic siRNA product candidatesthat are being evaluated in clinical trials for five different disease indications.

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