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Introduction:Emerging evidences indicate that osteoclasts may direct osteoblasts to regulate bone formation,and that the dysregulation of microRNAs (miRNAs) plays a crucial pathophysiological role on skeletal disorders with a reduction in bone formation.Our previous work demonstrated that exosomal miR-214 transferred from osteoclast could inhibit osteoblast activity in vitro.Here we further showed that osteoclast-derived exosomal miR-214 could inhibit osteoblastic bone formation in vivo.