【摘 要】
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Background: Colorectal cancer (CRC) can be cured when diagnosed in its early stages.Mostly due to poor compliance towards invasive screening procedures, detection rates for adenoma and early CRCs are
【机 构】
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CHUV, University Hospital Lausanne Switzerland
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Background: Colorectal cancer (CRC) can be cured when diagnosed in its early stages.Mostly due to poor compliance towards invasive screening procedures, detection rates for adenoma and early CRCs are still low.Available non-invasive screening tests have unfortunately low sensitivity and specificity performances.Therefore, there is a large unmet need calling for a cost-effective, reliable and non-invasive test to screen for early neoplastic and pre-neoplastic lesions.Objective: To develop a routine screening test based on a nucleic acids multi-gene assay performed on peripheral blood mononuclear cells (PBMCs) that can detect early CRCs and adenomas.Two distinct biomarker signatures are used to separate patients without neoplastic lesion from those with cancer (named COLOX 1 test), respectively from those with adenoma (named COLOX 2 test).A pilot study showed excellent results for the Colox-test 1 and 2: COLOX 1 and 2 tests have successfully separated patients without neoplastic lesion from those with CRC (sensitivity 70%, specificity 90%, AUC 0.88), respectively from those with adenoma bigger than lcm (sensitivity 61%, specificity 80%, AUC 0.80).6/24 patients in the 1BD group have a positive COLOX 1 test.Actually we finished a validation study of this test.-Test in more than 1500 patients (control subjects, patients with adenomas and colorectal cancer) are under analysis.Preliminary results are confirming the excellent results of the pilot study.The results of the validation study will be presented in Beijing.Conclusion: These two COLOX tests seem to confirm the results of the pilot study.The next step is a prospective controlled study comparing FOBT vs Colox vs colonoscopy.
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