Design, Synthesis and Pharmacological Evaluation of 4,5-Diarylisoxazols Bearing Amino Acid Residues

• 作 者: Chi Zhang Liping Sun Ao Zhang
• 机 构: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
• 出 处: 2016年长三角药物化学研讨会
• 发表日期: 2016年11期
• 关键词: Hsp90 inhibitor Amino acid Antitumor activity

　　Hsp90 is a molecular chaperone responsible for facilitating maturation of client proteins include oncogenic tyrosine kinase,transcription cofactors and cell-cycle proteins,and has long been recognized as a viable molecular target for cancer therapy.The majority of Hsp90 inhibitors currently in the clinic are Hsp90 N-terminal inhibitors that interact with the ATPase binding site in the N-terminal of Hsp90.