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  5. Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based sc

Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based sc

来源 :2016年长三角药物化学研讨会 | 被引量 : 0次 | 上传用户：ljl640211
【摘 要】
：
Major research efforts have been devoted to the discovery and development of compounds that inhibit the protein-protein interaction between HIF-1α and the von Hippel-Lindau protein (pVHL),the substrat
【作 者】
：
Xin Xue hai-qing zhang 
【机 构】
：
Department of Medicinal Chemistry, Nanjing University of Chinese Medicine,Nanjing 210038, China
【出 处】
：
2016年长三角药物化学研讨会
【发表日期】
：
2016年11期
【关键词】
：
HIF-1 α pVHL shape-based screening cascade docking stroke 
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　　Major research efforts have been devoted to the discovery and development of compounds that inhibit the protein-protein interaction between HIF-1α and the von Hippel-Lindau protein (pVHL),the substrate recognition subunit of an E3 ligase,and an important target in cancer,chronic anemia,and ischemia.It is particularly urgent to discover more inhibitors because only one class of compounds are available to interdict the HIF-1 α/pVHL interaction currently.
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