论文部分内容阅读
2-硫代喹唑啉二酮类衍生物的设计、合成以及抗肿瘤活性研究
【机 构】
：
南京中医药大学
【出 处】
：
2016年长三角药物化学研讨会
【发表日期】
：
2016年11期
其他文献
Theoretical Study on the Interaction between PDZ Domain Inhibitors and nNOS PDZ Domain Using a Polar
会议
Theoretical Simulation of Electronic Circular Dichroism Spectroscopy and Optical Rotations of Chaeto
会议
Analysis of binding interactions between scutellarein methyl derivatives and bovine serum albumin us
Scutellarin (1) was readily hydrolyzed into scutellarein (2) in the intestine and then metabolited into methylated,sulfated or glucuronidated forms.
会议
6-O-methyl-scutellarein (Figure 1),as the main metabolite of scutellarin (Figure 1) in vivo,has not been reported about its protective effects.
Histone deacetylases (HDAC) enzyme plays a significant role in transcriptional regulation by modifying the core histones of the nucleosome,therefore it has emerged as an important therapeutic target f
Synthesis of liguzinediol acetyl amino acid ester prodrugs and their biological evaluation as promis
The liguzinediol was a potential drug for the treatment of heart failure with high effect and low safety risk.However,in vivo pharmacokinetic study showed elimination half-life (t1/2) was too short,ac
Liguzineiol has been recently discovered as a potential agent for treatment of heart failure with low safety risk.In this manuscript,we have undertaken a systematic exploration of the liguzinediol pol