【摘 要】
：
探讨母体和新生儿对氧磷酶2基因(PON2)的多态性分布,及其对低出生体重的影响.采用病例—对照研究方法,收集低出生体重与正常出生体重新生儿及其母亲的全血样本,通过聚合酶链
【机 构】
：
公共卫生安全教育部重点实验室上海200032;复旦大学公共卫生学院环境卫生学教研室上海200032南通市疾病预防控制中心江苏南通226006
【出 处】
：
上海市环境科学学会2010年学术年会
论文部分内容阅读
探讨母体和新生儿对氧磷酶2基因(PON2)的多态性分布,及其对低出生体重的影响.采用病例—对照研究方法,收集低出生体重与正常出生体重新生儿及其母亲的全血样本,通过聚合酶链反应—限制性内切酶片断长度多态性(PCR-RFLP)的方法,检测其PON2基因148位点的基因型,并统计分析PON2 148基因多态性与低出生体重间的关联.单因素分析结果显示;PON2 Gly148Gly突变纯合子基因型/Alα148Gly突变杂合子基因型与Alα148Ala野生纯合子基因型比较,新生儿PON2 148基因多态性导致低出生体重的危险性增加(OR=2.494,95％Cl为1.044～5.957).结论为新生儿PON2 148基因多态性与其低出生体重相关.
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