【摘 要】
：
Preclinical cancer models are commonly based on use of human cancer cell lines, such models, while valuable, in general do not adequately predict the efficacy of anticancer agents in the clinic To dev
【机 构】
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Department of Cancer Endocrinology BC Cancer Agency-Cancer Research Centre Canada
【出 处】
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BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Preclinical cancer models are commonly based on use of human cancer cell lines, such models, while valuable, in general do not adequately predict the efficacy of anticancer agents in the clinic To develop more representative in vivo models for human cancer, efforts have been made to grow intact patients tumor tissue in immuno-deficient mice.Unfortunately, the tumor take rate was low and successful growth of tumors was reached only sporadically when the tumors were highly advanced Recently, we have developed a procedure for successfully grafting and serially transplanting primary human cancer tissues in mice.We have consistently achieved high tumor take rates (>95%) fora variety of low and higher grade malignancies, including cancers of prostate, ovary, kidney, lung and pancreas.In this presentation, foci will be on the properties of grafted cancer tissue, potential applications of the models (unpublished data) and possible collaborations in the future.
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