【摘 要】
：
Protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) control protein tyrosine phosphorylation.Studies in the last two decades have provided a myriad of information on PTKs in the d
【机 构】
：
Department of Molecular Oncology, SRB-3 H.Lee Moffitt Cancer Center and Research Institute USA
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) control protein tyrosine phosphorylation.Studies in the last two decades have provided a myriad of information on PTKs in the development of hurnan cancer.Although from the in vitro biochemical reaction point of view, PTPs catalyze the opposite reaction of PTKs and are perceived as tumor suppressors, few PTPs have been established as tumor suppressors.To the contrary, increasing evidence suggests that PTPs could cooperate with PTKs to promote cancer development and progression.Shp2 (PTPN11) is a non-receptor PTP that contains two SH2 domains.It is auto-inhibited by its N-SH2 domain in resting cells.Shp2 is activated by PTK oncogenes through binding to specific docking proteins to mediate PTK signaling such as activation of Src, Ras, and Erk MAP kinases.
其他文献
In this study we combine 1H MRS and pattern recognition (PR) methods-partial least squares discriminant analysis (PLS-DA) and orthogonal signal correction (OSC)-in order to investigate the response of
Pleomorphic Adenoma Gene 1 (PLAG1) is the founding member of a subfamily of zinc finger transcription factor genes.PLAG1, on human chromosome 8q12, encodes an essentially developmentally regulated pro
Patients with uterine leiomyosarcoma (LMS) typically present with vaginal bleeding, pain, and a pelvic mass, with atypical presentations of hypercalcemia and eosinophilia also being reported.Radiograp
Sub-cellular, i.e.organelle-specific drug delivery is emerging as the new frontier in drug delivery.It has become more and more evident that the efficiency and efficacy of drug action depends largely
Significant inter-patient variations in pharmacokinetics and pharmacodynamics have been associated with anticancer drugs, which generally have narrow therapeutic index.Reliable and practical bioanalyt
Epothilones, 16-member ring macrolides, originally isolated from myxobacterium Sorangium cellulosum in soil were shown to exert potent cytotoxicity via stabilization of microtubule polymerization, lik
The view that tumor metastasis and recurrence are caused by self-renewal and propagation of cancer stem cells is supported by a series of recent studies.Originally cloned as a dominant inhibitor of th
"Molecular Architecture" strategy focuses on the building of new compounds from scratch instead of the limited modifications starting from the natural products.It allows scientists to rationally desig
Filamin-A, also called actin-binding protein 280 (ABP-280), is predominantly a cytoplasmic protein.However, recent data suggest that a portion of this protein also resides in nucleus, and it interacts
Treatment of patients with metastatic soft-tissue and bone sarcomas remains a significant challenge with few new options.The kinase inhibitors imatinib and sunitinib have helped patients with gastroin