【摘 要】
：
Chaetoglobosin K (ChK) is a natural cytochalasan compound from acom fungus, Diplodiamacrospora.We found that ChK potently inhibits cell viability at concentration as low as 0.6 μM in ovarian cancer ce
【机 构】
：
Natural Science Division, Alderson-Broaddus College USA
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Chaetoglobosin K (ChK) is a natural cytochalasan compound from acom fungus, Diplodiamacrospora.We found that ChK potently inhibits cell viability at concentration as low as 0.6 μM in ovarian cancer cells.ChK also greatly inhibits secretion of the key angiogenesis mediators, Akt, HIF-1 α,and vascular epithelial growth factor (VEGF) by ovarian cancer cells.More importantly, ChK inhibits in-vitro and in-vivo angiogenesis induced by ovarian cancer cells, suppresses in-vivo tumor growth, and reduces migratory capability of human umbilical vein endothelial cells.By transfection of HIF-1αand Aktplasmids in luciferase assays we found that ChK executes its VEGF inhibition by mediating the hypoxia-independent downregulation of HIF-1α.
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