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Background: The detection of anti-Aquaporin-4 autoantibody (AQP-4 Ab) is crucial in order to detect patients who will develop neuromyelitis optica (NMO);however, there are few studies on the AQP-4 Ab serostatus of patients with neuromyelitis optica spectrum ON.Purpose:We analyzed the clinical and paraclinical features of neuromyelitis optica spectrum ON patients in China according to the patients AQP4-Ab serostatus.