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During the last several centuries farm animals were artificially selected for improvement of livestock production based on genetic variation which occurs in nature.In fact all the genetic variations are neutral and no orientated genetic variations can be created by human.Recently advancedgenetic engineering are developed very fast and have been applied to generate targeted geneticmutation in animal, which display a great potential for further improvement of animal productionefficiency to meet the food as well as the health requirements of a rapidly increasing world population.