The new Immunosuppressant, isogarcinol, binds directly to itstarget enzyme calcineurin, unlike cyclo

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：lxbyftk

【摘要】

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【作者】

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Juren Cen Mengqi Wang Guohua Jiang Yanxia Yin Zhenyi Su Li Tong Jing Luo Yipeng Ma Qun Wei

【机构】

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Department of Biochemistry and Molecular Biology, Beijing Normal University, Gene engineering and Bi

【出处】

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

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2014年3期

【关键词】

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isogarcinol calcineurin isothermal titration calorimetry fluorescences pectrosco

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　　Isogarcinol, a bioactive polyisoprenylated benzophenone derivative isolated fromGarcinia mangostana L., has been shown previously to exert a strong inhibitory effect oncalcineurin and is thus a potential oral, low-toxicity immunomodulatory drug.In thepresent study, enzyme kinetic analysis showed that inhibition of calcineurin by isogarcinolwas competitive.

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The new Immunosuppressant, isogarcinol, binds directly to itstarget enzyme calcineurin, unlike cyclo

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