Letrozole improves the sensitivity of cisplatin through downregulationof FEN1 expression in breast c

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:b999123
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Recent researches demonstrated that Flap endonuclease 1(FEN1) is over-expressed inbreast cancer cells and its expression may be up-regulated by estrogen (E2).Testosteronecould be transformed into E2 by aromatase which could be inhibited by aromatase inhibitorsuch as letrozole.
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