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MDRG0 peptides are derived from the protein RasGAP,which is a regulator of Ras and Rho GTP binding proteins.RasGAP is a caspase substrate with 2 cleavage sites.Resulting fragments negatively or positively regulate apoptosis depending on the extent of caspase activation and the sequence generated by caspase cleavages.A small and specific peptide sequence sensitizing tumor cells to genotoxins was developed based on RasGap cleavage.This sequence has been rendered cell permeable by linking it to different peptides with basic residues (including TAT).These peptides efficiently sensitize cancer cells to genotoxin-induced apoptosis whereas no effect was observed on normal cells.We will also report toxicity and proof of concept data in animal models which confirm that MDRG0 peptide shall improve significantly the clinical efficacy of chemotherapies of cancers by decreasing side effects and increasing antitumor effect.