【摘 要】
：
ADAMTS-4 and ADAMTS-5,also referred to as aggrecanase-1 and-2,respectively,play a key role in the pathological breakdown of the cartilage extracellular matr
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
ADAMTS-4 and ADAMTS-5,also referred to as aggrecanase-1 and-2,respectively,play a key role in the pathological breakdown of the cartilage extracellular matrix observed in osteoarthritis (OA).These proteinases belong to the recently discovered ADAMTS family which includes 19 members.Both proteinases are glutamyl endopeptidases and cleave aggrecan,the major proteoglycan in articular cartilage responsible for resisting compressive forces in the joint,at 5 specific sites:Glu373-Ala374,Glu1545-Gly1546,Glu1714-Gly1715,Glul819-Ala1820,and Glu1919-Leu 1920 bonds (human sequence),resulting in cartilage destruction.
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