【摘 要】
：
Chronic allograft rejection (CAR) is a major cause of allograft failure in clinical transplantation; however the molecular mechanisms underlying CAR are poo
【机 构】
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DepartmentofPathologyandLaboratoryMedicineUniversityofWiscousin-MadisonUSA
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
Chronic allograft rejection (CAR) is a major cause of allograft failure in clinical transplantation; however the molecular mechanisms underlying CAR are poorly understood.Indeed,identifying the molecules involved in CAR is important for understanding the molecular mechanisms underlying CAR,and for designing therapeutic strategies to prolong allografl survival.Smooth muscle cells (SMC) play an important role in the pathogenesis of CAR by contributing to the thickening of the intima of the arteries and the loss of lumen; thus,regulating SMC processes should be useful for controlling CAR.We showed in a well-established rhesus monkey renal transplant model that SBP-1,a protein implicated intracellular protein trafficking and secretion,localizes preferentially to SMC in vivo.
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