【摘 要】
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Background and purpose: Oxidative stress with high production of reactive oxygen species (ROS) has been implicated in the pathogenesis of atherosclerosis.Reduced glutathione (GSH) is a cytosolic antio
【机 构】
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State Key Laboratory of Medicinal Chemical Biology, Nankai University
【出 处】
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2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
Background and purpose: Oxidative stress with high production of reactive oxygen species (ROS) has been implicated in the pathogenesis of atherosclerosis.Reduced glutathione (GSH) is a cytosolic antioxidant to reduce cellular ROS levels.Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme regulating cellular GSH production.Several studies have demonstrated the importance of GCL in the development of atherosclerosis.Macrophage CD36 uptakes oxidized low-density lipoprotein (oxLDL) thereby facilitating foam cell formation.
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