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ABSTGRACT: Aim: To analyze the metabolic profiles in the plasma samples of lymphoma patients as well as healthy controls and further explore potential biomarkers related to lymphoma.Methods: Ultra high performance liquid chromatography –Q Exactive orbit trap high-resolution mass spectrometry was applied to process the plasma samples of 12 lymphoma patients and 12 healthy volunteers.Orthogonal to partial squares discriminant analysis(OPLS-DA)was performed to identify differences in metabolic profiles between the two groups and select potential biomarkers of lymphoma.Results: Multivariate statistical analysis yielded a significant distinction in the metabolic profiles between lymphoma patients and healthy volunteers.Compared with healthy controls,the contents of aspartic acid and 4-pyridoxate were significant higher in plasma of lymphoma patients(p<0.05),while the contents of L-α-glycerylphosphorylcholine,linoleic acid,decanoylcarnitine,phenylalany-lphenylalanine,threonic acid and taurine were obviously lower(p<0.05).Conclusions: 8 metabolites with significant differences found via metabonomics were aspartic acid,4-pyridoxate,glycerylphosphorylcholine,linoleic acid,decanoylcarnitine,phenylalanylphenylalanine,taurine and threonic acid,which might be potential biomarkers associated to lymphoma.