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β-Adrenergic agonists may pose potential risk and result in a series of harmful effects on human health,and the method for direct direction of β-adrenergic agonists is still challenging.Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation.However,it suffers from low sensitivity when typically dealing with practical samples with very complex matrices.In this study,molecularly imprinted membrane electrospray ionization(MIM-ESI)Mass Spectrometry was developed by integrated molecular imprinting technology with membrane electrospray ionization for quantification of β-adrenergic agonists.1 Modified hydrophilic polyvinylidene difluoride(PVDF)membrane was activated and synthesized,and ractopamine was used as the template molecule.2 Human urine samples spiked with clenbuterol hydrochloride(CLE)and salbutamol sulfate(ABS)were detected by MIM-ESI MS.Experiments showed that MIM-ESI MS has satisfactory performances for directly rapid quantification of targeted analytes in complex samples.LOQs for both CLE and ABS were 0.1 ng·mL-1(Figure 1).These results demonstrated that MIM-ESI MS could potentially be very useful for multiple applications with the capability of quantifying low concentration analytes in complex samples.