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Apoptosis of osteoblasts triggered by high-dose glucocorticoid (GC) has been identified a major cause of osteoporosis.However,the underlying molecular mechanisms accounting for this action remain elusive,which impeded the prevention and cure of this side effect.Sulforaphane (SPF) is a naturally occurring isothiocyanate that has huge health benefits for humans.In this study,by using osteoblastic MC3T3-E 1 cells as a model,we demonstrate the protective effects of SPF against dexamethasone (Dex)-induced apoptosis of and elucidate the underlying molecular mechanisms.