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Objective To explore the feasibility and preliminary effect of clamping drainage on reducing blood loss after minimally invasive unicondylar knee arthroplasty(MI-UKA).Methods Between August 2011 and July 2012,117 consecutive patients(117 knees)with unicompartmental knee osteoarthritis were treated with MI-UKA.All cases were prospectively randomized into continuous drainage group(n=25),clamping 4h group(n=41)and clamping 6h group(n=51).Pre-and post-operative hemoglobin(Hb),hematocrit(Hct),drainage volume,complications and knee joint function by HSS score system were compared.Results There was no statistically significant difference in terms of demographic data among three groups.of The total drainage volume,postoperative Hb and Hct values in the early clamping group(4h group and 6h group)were significantly lower than that in the continuous drainage group(P<0.01).The drainage in the clamping 4h group was significantly more than that in theclamping 6h group at all time points(24h,36h and 48h after surgery)(P<0.05).The Hb value after 48h decreased significantly(P<0.05),whereas there was no significant difference in postoperative 48h Hct value(P>0.05).VAS scores decreased significantly(P<0.01)in the continuous drainage group compared with the early clamping group in the second day and seventh day,while there was no significant difference(P>0.05)between clamping 4h group and clamping 6h group.After two weeks,the VAS scores between three groups were not significantly different(P>0.05).No differences in postoperative complications and knee function score were recorded among the three groups(P>0.05).Conclusions Early clamping drainage can significantly reduce blood loss after MI-UKA without increasing the associated postoperative complications and achieve satisfactory functional recovery.Our results also show that delaying release of the drains by six hour is a good time to choose.