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Evidence suggests that alterations in histone modifications are crucial in cancer development and progression.Among these, histone 3 lysine 4 trimethylation (H3K4me3) is found in promoters of active genes and is proposed to promote gene expression.To evaluate the H3K4me3 binding pattern across the genome among 3 cancer patients in a Chinese pedigree with a heterozygous stop codon mutation in MLL3 (coding a histone H3K4me3 methyltransferase) segregating with colorectal carcinoma (CRC) and acute myeloid leukemia (AML) and a mutation-free normal control, ChIP-chip analyses were performed to determine which promoters coprecipitated with the H3K4me3 antibody in both patients and control.The pulled-down genes were mapped to KEGG pathways.